1988-1992，复旦大学生命科学院微生物系，本科生；1992-1995，北京生物制品研究所医学免疫学专业，硕士研究生；1995-1998，第四军医大学生物化学与分子生物学专业，博士研究生；1998-2000，第四军医大学生物化学与分子生物学教研室，讲师；2000-2004，美国新泽西医科和牙科大学Robert Wood Johnson医学院，博士后；2004-2005，北京生命科学研究所，博士后；2005-今，yl6809永利官网，教授。2005年入选北京市科技新星计划和教育部新世纪优秀人才支持计划；2006-2009年任细胞生物学系系主任；2009-2022年任细胞生物学研究所所长、细胞增殖及调控生物学教育部重点实验室主任；2021年4月至今任生物学系系主任。担任北京细胞生物学会理事，中国生物化学与分子生物学会脂质与脂蛋白专业委员会委员。主持的本科生《分子生物学》双语课程被评为国家双语示范课程和国家精品课程。在Molecular Cell，Autophagy，Journal of Biological Chemistry，Journal of Lipid Research等学术刊物上发表SCI论文36篇，授权国家发明专利6项。
生物活性脂质分子LPA的代谢调控及其生理和病理意义：重点研究LPA生成关键酶Autotaxin(ATX)的表达调控机制，阐释ATX-LPA-LPA受体通路在免疫调控、肿瘤发生以及肥胖相关疾病中的作用。
应激条件下肿瘤细胞的生长调控机制：重点研究在缺氧、营养缺乏、DNA损伤等应激条件下，肿瘤细胞增殖、自噬和凋亡的调控机制。
应激条件下细菌的生长调控机制：研究毒素-抗毒素系统(Toxin-antitoxin system)和Pup-蛋白酶体系统在分枝杆菌生长调控中的作用及其分子机制，揭示相关机制在结核分枝杆菌致病中的作用，探讨结核病防治的新方法。
研究性论文
1. Yang Long, Yuqin Wang, Mengxia Qu, Di Zhang, Xiaotian Zhang* and Junjie Zhang* (2023). Combined inhibition of EZH2 and the autotaxin-LPA-LPA2 axis exerts synergistic antitumor effects on colon cancer cells. Cancer Letters,566,216226.
2. Mengxia Qu, Yang Long, Yuqin Wang, Nan Yin, Xiaotian Zhang*, Junjie Zhang* (2023). Hypoxia Increases ATX Expression by Histone Crotonylation in a HIF-2α-Dependent Manner. International Journal of Molecular Sciences,24,7031.
3. Mengmiao Li, Qian Huang, Weidi Zhang, Yinghua Cao, Zhanxin Wang, Zhenwen Zhao, Xiaotian Zhang and Junjie Zhang* (2022). A Novel Acyl-AcpM-Binding Protein Confers Intrinsic Sensitivity to Fatty Acid Synthase Type II Inhibitors in Mycobacterium smegmatis. Frontiers in Microbiology, 13:846722. doi: 10.3389/fmicb.2022.846722.
4. Xin Xu, Yihua Zhang, Junjie Zhang*, and Xiaotian Zhang* (2020). NSun2 promotes cell migration through methylating autotaxin mRNA. Journal of Biological Chemistry，295 (52),18134-18147.
5. Yuqin Wang, Lin Lvy, Xiaotian Zhang*, and Junjie Zhang* (2019). Autotaxin is a novel target of microRNA-101-3p. FEBS Open Bio. 9(4):707-716.
6. Xiaodong Chi, Yunqing Chang, Mengmiao Li, Jin Lin, Yi Liu, Chuanyou Li, Shenjie Tang and Junjie Zhang*(2018). Biochemical characterization of mt-PemIK, a novel toxin-antitoxin system in Mycobacterium tuberculosis. FEBS Letters 592(24):4039-4050.
7. Shuhong Sun, Ran Wang, Jianwen Song, Ming Guan, Na Li, Xiaotian Zhang, Zhanwen Zhao, Junjie Zhang* (2017). Blocking gp130 signaling suppresses autotaxin expression in adipocytes and improves insulin sensitivity in diet-induced obesity. Journal of Lipid Research 58(11):2102-2113. (Cover story)
8. Lin Lyu, Baolu Wang, Chaoyang Xiong, Xiaotian Zhang, Xiaoyan Zhang, and Junjie Zhang* (2017). Selective export of autotaxin from the endoplasmic reticulum. Journal of Biological Chemistry 292(17):7011-7022.
9. Shuhong Sun, Xiaotian Zhang*, Lin Lyu, Xixi Li, Siliang Yao, and Junjie Zhang* (2016). Autotaxin expression is regulated at the post-transcriptional level by the RNA-binding proteins HuR and AUF1. Journal of Biological Chemistry 291(50):25823-25836.
10. Xuejie Chen, Chandan Li, Li Wang, Yi Liu, Chuanyou Li, Junjie Zhang* (2016) The Mechanism of Mycobacterium smegmatis PafA Self-Pupylation. PLoS ONE 11(3): e0151021. doi:10.1371/journal.pone.0151021.
11. Jianwen Song, Ming Guan, Zhenwen Zhao, Junjie Zhang* (2015) Type I Interferons Function as Autocrine and Paracrine Factors to Induce Autotaxin in Response to TLR Activation. PLoS ONE 10(8): e0136629. doi:10.1371/journal.pone.0136629.
12. Song Li, Bin Guo, Jianwen Song, Xiaoli Deng, Yusheng Cong, Pengfei Li, Ke Zhao, Lihong Liu, Gang Xiao, Feng Xu, Yingjiang Ye, Zhenwen Zhao, Menggang Yu, Yan Xu, Jianli Sang*, Junjie Zhang* (2013). Plasma choline-containing phospholipids: Potential biomarkers for colorectal cancer progression. Metabolomics 9(1):202-212.
13. Xiaolei Xie, Li Le, Yanxin Fan, Lin Lv, Junjie Zhang* (2012). Autophagy is induced through the ROS-TP53-DRAM1 pathway in response to mitochondrial protein synthesis inhibition. Autophagy 8(7): 1071-1084.
14. Song Li, Chaoyang Xiong, Junjie Zhang* (2012). ATX and LPA receptor 3 are coordinately up-regulated in lipopolysaccharide-stimulated THP-1 cells through PKR and SPK1-mediated pathways. FEBS Letter 586(6):792-797.
15. Song Li, Baolu Wang, Yan Xu, Junjie Zhang* (2011). Autotaxin is induced by TSA through HDAC3 and HDAC7 inhibition and antagonizes the TSA-induced cell apoptosis. Molecular Cancer 10(1):18 doi:10.1186/1476-4598-10-18.
16. Song Li, Junjie Zhang* (2009) Lipopolysaccharide Induces Autotaxin Expression in Monocytic THP-1 Cells. Biochemical and Biophysical Research Communications 378(2):264-268.
17. Longxuan Zhao, Junjie Zhang* (2008) Biochemical characterization of a chromosomal toxin-antitoxin system in Mycobacterium tuberculosis. FEBS Letter 582(5)710-714.
18. Motoo Suzuki, Junjie Zhang, Mohan Liu, Nancy A. Woychik and Massayori Inouye* (2005). Single protein production in living cells facilitated by an mRNA interferase. Molecular Cell 18(2):253-261.
19. Junjie Zhang, Yonglong Zhang, Ling Zhu, Motoo Suzuki and Masayori Inouye* (2004). Interference of mRNA function by sequence-specific endoribonuclease PemK. Journal of Biological Chemistry 279(20):20678-20684.
20. Yonglong Zhang#, Junjie Zhang#, Klaus P. Hoeflich, Mitsuhiko Ikura, Guoliang Qing, Masayori Inouye* (2003). MazF cleaves cellular mRNAs specifically at ACA to block protein synthesis in Escherichia coli. Molecular Cell 12(4):913-923. (#Authors contributed equally).
21. Junjie Zhang, Yonglong Zhang and Masayori Inouye* (2003). Characterization of the interactions within the mazEF addiction module of Escherichia coli. Journal of Biological Chemistry 278(34):32300-32306.
22. Junjie Zhang, Yonglong Zhang and Masayori Inouye* (2003). Thermotoga maritima MazG protein has both nucleoside triphosphate pyrophosphohydrolase and pyrophosphatase activity. Journal of Biological Chemistry 278(24): 21408-21414.
23. Junjie Zhang, Masayori Inouye* (2002). MazG, a nucleoside triphosphate pyrophosphohydrolase, interacts with Era, an essential GTPase in Escherichia coli. Journal of Bacteriology 184(19): 5323-5329.
综述
24. 戴炜，李梦淼，张俊杰*（2023）. Pup-蛋白酶体系统作用机制和生物学功能. 生物化学与生物物理进展 50（4）：725-739.
25. 张地，张俊杰*（2022）.Autotaxin表达调控机制及其生物学功能. 中国科学：生命科学，52（8），1148-1162.
26. Xiaotian Zhang, Mengmiao Li, Nan Yin, Junjie Zhang* (2021). The Expression Regulation and Biological Function of Autotaxin. Cells, 10(4):939. doi:10.3390/cells10040939
27. 尹楠，张俊杰*（2021）. Autotaxin-LPA轴在肥胖及其相关疾病中的作用. 生物化学与生物物理进展 48（7）, 768-778.
28. 王晓蕾，赵龙旋，张俊杰*（2008）. 细菌毒素-抗毒素系统的研究进展. 生物化学与生物物理进展 35（9）：991-997.
