2007-2011年于山东大学生物技术专业学习,获理学学士学位。2011-2016年于南开大学微生物学专业学习,获理学博士学位。2016-2018年在yl6809永利官网进行博士后研究,并于2018年底留校任教。主持中国博士后科学基金1项,国家自然科学基金1项,参与多项国家自然科学基金项目,在国内外发表论文10余篇。
以人类条件致病真菌隐球菌为研究对象,主要开展以下三方面的研究工作:
1.新生隐球菌中产生大量非编码sRNA,对新生隐球菌乃至真菌领域非编码小RNA的起源与发生、生物学功能等进行研究。
2.新生隐球菌是隐球菌中主要的临床致病菌,对新生隐球菌的致病机制进行研究。
3.格特隐球菌分子生物学技术的建立及致病性研究。
1. Zhang P, Wang Y, Li C, Ma X, Ma L, Zhu X*. Simplified all-in-one CRISPR-Cas9 construction for efficient genome editing in Cryptococcus species. Journal of Fungi, 2021, 7, 505.
2. Li C, Ma X, Deng J, Li J, Liu Y, Zhu X, Liu J*, Zhang P*. Machine learning-based automated fungal cell counting under a complicated background with ilastik and ImageJ. Engineering in Life Sciences, 2021, 1–9.
3.Zhang P, Li C, Huo L, Xiang B, Rahim K, Hao X, Zhu X*. Role of the fungus-specific flavin carrier Flc1 in antifungal resistance in the fungal pathogen Cryptococcus neoformans. Medical Mycology, 2019, 57(4): 468–477.
4. Huo L#, Zhang P#, Li C, Rahim K, Hao X, Xiang B, Zhu X*. Genomewide identification of circRNAs in pathogenic basidiomycetous yeast Cryptococcus neoformans suggests conserved circRNA host genes over kingdoms. Genes, 2018, 9(3): 118.
5. Zhang P, Zhang D, Zhao X, Wei D, Wang Y, Zhu X*. Effects of CTR4 deletion on virulence and stress response in Cryptococcus neoformans. Antonie van Leeuwenhoek Journal of Microbiology, 2016, 109(8): 1081-1090.
6. Zhang P, Wei D, Li Z, Sun Z, Pan J, Zhu X*. Cryptococcal phosphoglucose isomerase is required for virulence factor production, cell wall integrity and stress resistance. FEMS Yeast Research, 2015, 15(7): fov072.
7. Wang Y, Wei D, Zhu X, Pan J, Zhang P, et al. A ‘suicide’ CRISPR-Cas9 system to promote gene deletion and restoration by electroporation in Cryptococcus neoformans. Scientific Reports, 2016, 6: 31145.